2012

Scientific articles

1)       Feb 15th, Odland HH, Kro GA, Edvardsen T, Thaulow E, Saugstad OD: Impaired Diastolic Function and Disruption of the Force-Frequency Relationship in the Right Ventricle of Newborn Pigs Resuscitated With 100% Oxygen. Neonatology 2012;101:147-153

2)       Dec 15th, Russell K, Smiseth OA, Gjesdal O, Qvigstad E, Sjåstad I, Opdahl A, Skulstad H, Edvardsen T, Remme EW: Mechanisms of Prolonged Electro-Mechanical Delay in Late Activated Myocardium during Left Bundle Branch Block. Am J Physiol Heart Circ Physiol 2011 Dec;301(6):H2334-43.

3)       Feb 15th, Edvardsen T, Haugaa KH: Republished: Imaging assessment of ventricular mechanics. Postgrad Med J 2012;88:105-112.

4)       March 13th, Edvardsen T: The continued discovery of left atrial function. Eur Heart J – CV Imag 2012 Mar;13(3):203-4 editorial

5)       March 15th, Russell K, Eriksen M, Aaberge L, Wilhelmsen N, Skulstad H, Remme E, Haugaa KH, Opdahl A, Fjeld JG, Gjesdal O, Edvardsen T, Smiseth OA: A novel clinical method for quantification of regional left ventricular pressure-strain area – a non-invasive index of myocardial work. European Heart J 2012 33(6):724-33

6)       May 29th, Odland HH, Brun H, Sejersted Y, Dalen M, Edvardsen T, Saugstad OD, Thaulow E: Myocardial Longitudinal Peak Systolic Acceleration (pSac): Relationship to Ejection Phase, Pressure and Contractility. Echocardiography 2012 May;29(5):541-53.

7)       June 25th,  Haugaa KH, Goebel B, Dahlslett T, Meyer K, Jung C, Lauten A, Figulla HR, Poerner TC, Edvardsen T: Risk assessment of ventricular arrhythmias in patients with non ischemic dilated cardiomyopathy by strain echocardiography J Am Soc Echocardiogr 2012 Jun;25(6):667-73.

8)       May 15th, Sikkeland LI, Dahl CP, Ueland T, Andreassen AK, Gude E, Edvardsen T, Holm T, Yndestad A, Gullestad L, Kongerud J, Aukrust P, Øie E: Increased Levels of Inflammatory Cytokines and Endothelin-1 in Alveolar Macrophages from Patients with Chronic Heart Failure. PLoS ONE 2012;7(5):e36815.

9)       July 25th, Vartdal T, Pettersen E, Helle-Valle T, Lyseggen E, Andersen K, Smith H-J, Aaberge L, Ihlen H, Smiseth OA, Edvardsen T: Identification of Viable Myocardium in Acute Anterior Infarction Using Duration of Systolic Lengthening by Tissue Doppler Strain: A Preliminary Study J Am Soc Echocardiogr 2012 Jul;25(7):718-25

Identification of Viable Myocardium in Acute Anterior Infarction Using Duration of Systolic Lengthening by Tissue Doppler Strain: A Preliminary Study

10)   April 21st, Haugaa KH, Edvardsen T: Myocardial contraction and Long-QT syndrome Trends CV Medicine 2012 Apr;21(3):65-9

11)   Sept 25th, Sarvari SI, Gjesdal O, Gude E, Arora S, Andreassen AK, Gullestad L, Geiran OR, Edvardsen T: Early postoperative Left Ventricular function is a Powerful of 1-Year Mortality in Heart Transplant Recipients J Am Soc Echocardiogr 2012 Sep;25(9):1007-14.

12)   Sept 18th, Opdahl A, Remme EW, Helle-Valle T, Edvardsen T, Smiseth OA: Myocardial relaxation, restoring forces and early-diastolic load are independent determinants of left ventricular untwisting rate. Circ 2012 Sep 18;126(12):1441-51.

13)   Aug 24th, Goebel B, Handrick V, Lauten A, Fritzenwanger M, Schütze J, Otto S, Figulla HR, Edvardsen T, Poerner TC, Jung C: Impact of acute normobaric hypoxia on regional and global myocardial function: a speckle tracking echocardiography study. International Journal of Cardiovascular Imaging DOI: 10.1007/s10554-012-0117-2

14)   Sept 18th, Smedsrud MK, Sarvari SI, Haugaa KH, Gjesdal O, Ørn S, Aaberge L, Smiseth O, Edvardsen T: Duration of myocardial systolic lengthening predicts the presence of significant coronary artery disease J Am Coll Cardiol 2012 Sep 18;60(12):1086-93.

15)   Oct 6th, Gullestad L, Ørn S, Dickstein K, Eek C, Edvardsen T, Aakhus S, Askevold ET, Michelsen A, Bendz B, Skårdal R, Smith HJ, Yndestad A, Ueland T, Aukrust P. Intravenous immunoglobulin does not reduce left ventricular remodeling in patients with myocardial dysfunction during hospitalization after acute myocardial infarction. International Journal of Cardiology 2012 Oct S0167-5273(12)01198-9.

16)   March 15th, Snare SR, Torp H, Orderud F, Haugen BO, "Real-time scan assistant for echocardiography", IEEE Trans Ultrason Ferroelectr Freq Control. 2012 Mar;59(3):583-9.

17)   June 28th, Jasaityte R, Heyde B, Ferferieva V, Amundsen B, Barbosa D, Loeckx D, Kiss G, Orderud F, Claus P, Torp H, D'hooge J, "Comparison of a new methodology for the assessment of 3D myocardial strain from volumetric ultrasound with 2D speckle tracking", Int J Cardiovasc Imaging. 2012 Jun;28(5):1049-60.

18)   Nov 15th, Snare SR, Mjølstad OC, Orderud F, Dalen H, Torp H, "Automated septum thickness measurement-A Kalman filter approach", Comput Methods Programs Biomed. 2012 Nov;108(2):477-86

19)   Jan 18th, A. Tveito, G. T. Lines, and M. Maleckar. "A note on a possible pro-arrhythmic property of anti-arrhythmic drugs aimed at improving gap-junction coupling", Biophysical Journal 102(2):231-37, 2012.

20)   April 15th, A. Tveito, G. T. Lines, J. E. Hake, and A. G. Edwards. Instabilities of the resting state in a mathematical model of calcium concentrations in cardiac myocytes, Mathematical Biosciences 236(2):97–107, 2012.

21)   March 15th, A. Tveito, G. T. Lines, M. E. Rognes, and M. M. Maleckar. An analysis of the shock strength needed to achieve defibrillation in a simplified mathematical model of cardiac tissue, International Journal of Numerical Analysis and Modeling  9(3):644-57, 2012.

22)   Oct 15th, A. Tveito, G. Lines, A. G. Edwards, M. M. Maleckar, A. Michailova, J. Hake, and A McCulloch.  A  Slow Calcium-Depolarization-Calcium waves may initiate fast local depolarization waves in ventricular tissue, Progress in Biophysics and Molecular Biology 110(2–3):295–304, 2012.

23)   Aug 15th, Harald Osnes and J. Sundnes. Uncertainty analysis of ventricular mechanics using the probabilistic collocation method. IEEE transactions on biomedical engineering, Aug;59(8):2171-9, 2012.

24)   July 16th, J. Sundnes, S. Wall, H. Osnes, T. Thorvaldsen, and A. McCulloch. Improved discretisation and linearisation of active tension in strongly coupled cardiac electro-mechanics simulations, Computer methods in biomechanics and biomedical engineering, epub ahead of print,  2012.

25)   Jan 1st, Wall ST, Guccione JM, Ratcliffe MB, Sundnes J. Electromechanical Feedback with reduced cellular connectivity alters electrical activity in an infarct injured left ventricle: a finite element model study. American Journal of Physiology - Heart and Circulatory Physiology. 2012; 302(1):H206-H214

26)   Oct 23rd, Rose RA, Belke DD, Maleckar MM, Giles WR. Ca2+ Entry Through TRP-C Channels Regulates Fibroblast Biology in Chronic Atrial Fibrillation. Circulation 126(17): 2039-41, 2012, editorial

27)   2012, Edvardsen T: Ekko i fremtiden – integrering av flere imaging-modaliteter? Hjerteforum 2012; 25 (1):72-73

28)   2012, Edvardsen T: Hvordan avbilde ventriklenes systoliske funksjon med ekkokardiografi? Best Practice 2012; 2(3) 18-24.

29)   2012, Hasselberg N, Sarvari SI, Edvardsen T: Kjemoterapi-indusert kardiotoksisitet ved kreftbehandling. Hjerteforum 2012; 25 (4):26-32.

 

Book/Article in book/Report

1)       May 22nd, Smiseth OA and Edvardsen T: Myocardial mechanics: Velocities, Strain, Strain Rate, Cardiac Synchrony, and Twist. Editor: Catherine M Otto: Practice of Clinical Echocardiography 4TH edition Saunders 2012 ISBN: 1437727654

2)       Sept, 2012, Sarvari SI and Edvardsen T: Imaging in Heart Failure. Advances in Heart Failure Management. Pages 34-45. Doi: 10.2217/ebo.11.239

 

Lecture/Presentation

Dissemination measures for users

1)       Aug 25th-29th, Edvardsen T., The best from Euroecho 2012. Left ventricular function. European Heart Meeting. ESC. Munich. Germany. Aug. 2012

2)       Aug 25th-29th, Edvardsen T, 2D wall motion tracking and transmural strain. European Heart Meeting. ESC. Munich. Germany. Aug. 2012

3)       June 29th-July 2nd, Edvardsen T., New Methods of Assessing Right Ventricular Function. 23rd Annual meeting. American Society of Echocardiography. Washington DC, USA. June/July 2012.

4)       June 29th-July 2nd, Edvardsen T., Achieving Precision in Measuring Left Ventricular Systolic Function with Echocardiography. 23rd Annual meeting. American Society of Echocardiography. Washington DC, USA. June/July 2012.

5)       April 5th-7th, Edvardsen T., Stress echocardiography, infarction, reperfusion injury and viability. Sofia, Bulgaria. April 2012 EAE Teaching Course, Organized by Bulgarian Society of Cardiology

6)       April 5th-7th, Edvardsen T., Prognostic value of deformation Imaging in ischemic cardiomyoapthy. Sofia, Bulgaria. April 2012 EAE Teaching Course, Organized by Bulgarian Society of Cardiology

7)       Feb 8th-10th, Edvardsen T., How does myocardial systolic lengthening relate to coronary artery disease? Myocardial Velocity and Deformation Imaging. Leuven, Belgium Feb 2012.

8)       Nov 2011, K Russell, M Eriksen, L Aaberge, N Wilhelmsen, EW Remme, A Opdahl, KH Haugaa, T Edvardsen, OA Smiseth: Novel Method For Noninvasive Myocardial Work Analysis in Patients With Left Bundle Branch Block. Circulation, Nov 2011; 124: A12700. (Abstract)

9)       Sept 20th- 21st, N. E. Hasselberg, T.Edvardsen, H. Petri, K E Berge, T. Leren, H.Bundgaard, K.H. Haugaa: Atrioventricular Conduction Delay predicts Ventricular Tachycardia in Lamin A/C Mutation Carriers. J Am Coll Cardiol. (Abstract supplement)

10)   March 22nd-25th, , R. M. ter Bekke, K. H. Haugaa, A. van den Wijngaard, T. Edvardsen, P. G. Volders. Electro-mechanical window is profoundly negative in genotyped long-QT patients: relation to arrhythmogenic risk. Heart Rhythm 2012. (Abstract  supplement)

11)  Aug 25th-29th, J. Saberniak, N.E. Hasselberg, A.G. Holst, T. Edvardsen, K.H. Haugaa: High level of physical activity may impair myocardial function in patients with arrhythmogenic right ventricular cardiomyopathy. European Heart Journal ESC Aug 2012, Munich. P1298. (Abstract supplement)

12)   Aug 25th-29th, K. Russell, M. Eriksen, E.W. Remme, K.H. Haugaa, H. Skulstad, T. Edvardsen, O.A. Smiseth: Wasted work fraction a novel method for assessing global and regional left ventricular function. European Heart Journal ESC Aug 2012, Munich. P2742.  (Abstract supplement)

13)   Aug 25th-29th, B. Goebel, V. Handrick, A. Lauten, M. Fritzenwanger, J. Schuetze, S. Otto, H.R. Figulla, T. Edvardsen, T.C. Poerner, C. Jung: Impact of acute normobaric hypoxia on regional and global myocardial function: a speckle tracking echocardiography study. European Heart Journal ESC Aug 2012, Munich. P4211.(Abstract supplement)

14)   Aug 25th-29th, A.G. Holst, K.H. Haugaa, P.G. Platonov, T. Edvardsen, C. Lundin, T. Gilljam, O. Eschen, J. Hansen, H. Bundgaard, J.H. Svendsen: Risk factors for sudden cardiac death: Results from the Nordic arrhythmogenic right ventricular cardiomyopathy registry. European Heart Journal ESC Aug 2012, Munich. P4129. (Abstract supplement)

15)   Aug 25th-29th, P.G. Platonov, A.G. Holst, K. Haugaa, T. Edvardsen, T. Gillijam, C. Lundin, O. Eschen, J. Hansen, H. Bundgaard, J.H. Svendsen: Performance of task force diagnostic criteria for identification of symptomatic patients in the nordic arrhythmogenic right ventricular cardiomyopathy registry. European Heart Journal ESC Aug 2012, Munich. P4143. (Abstract supplement)

16)   Aug 25th-29th, N.E. Hasselberg, T. Edvardsen, H. Petri, K.E. Berge, T.P. Leren, H. Bundgaard, K.H. Haugaa: The importance of atrioventricular conduction and myocardial function in ventricular arrhythmogenesis in lamin A/C mutation carriers. European Heart Journal ESC Aug 2012, Munich. P4735. (Abstract supplement)

17)   Aug 25th-29th, T. Dahlslett, B. Grenne, C. Eek, B. Sjoli, H. Skulstad, O.A. Smiseth, T. Edvardsen, H.Brunvand: Early strain echocardiography may exclude high-grade coronary artery stenosis in suspected non-ST-elevation acute coronary syndrome. European Heart Journal ESC Aug 2012, Munich. P5066. (Abstract supplement)

18)   Aug 25th-29th, K. Russell, M. Eriksen, J.G. Fjeld, S.I. Savari, T. Edvardsen1, O.A. Smiseth: Non-invasive regional work reflects myocardial metabolic demand in patients with left bundle branch block. European Heart Journal ESC Aug 2012, Munich. P5255. (Abstract supplement)

19)   Aug 25th-29th, W. Zahid, J. Johnson, C. Westholm, C. Eek, R. Skulstad, E. Fosse, R. Winter, T. Edvardsen: Mitral annular excursion in patients with suspected non-ST-elevation acute coronary syndrome can identify coronary occlusion and predict mortality. European Heart Journal ESC Aug 2012, Munich. P5070. (Abstract supplement)

20)   April 2012, Ongoing research at the CCI. Edvardsen T., Annual meeting. Inst for Surgical Research. Oslo.

21)   Sep 24th, Samset E, "Industry perspectives on RCN strategy for ICT research 2015-2025", RCN workshop, Oslo.

22)   Sep 26th, Samset E, "Experience with Marie Curie projects in academia and industry", RCN hosted visit by Alessandra Luchetti, Oslo.

23)   Aug 28th, Samset E, "Marie Curie ITN: from an accepted proposal to a successful ongoing project", SUMMER project summer school, Vienna – Austria

24)   Sept 2012, M. Lysaker, B. F. Nielsen, and P. Grøttum. On the Use of the Bidomain Model for Computing the Position and Size of Ischemic Regions; a Validation Study, In: Computing in Cardiology, 2012.

25)   Nov 2012, Joakim Sundnes, Samuel Wall, and Sjur Urdson Gjerald. Towards patient-specific models of strongly coupled cardiac electro-mechanics. Cardiac Physiome Workshop, San Diego, USA.

26)   July 2012, Joakim Sundnes and Samuel Wall. Computer models of electro-mechanical interactions in the contracting heart. Workshop on computational models in biomedicine, Federal University of Juiz de Fora, Brazil.

27)   July 2012, Joakim Sundnes and Samuel Wall. Numerical methods for strongly coupled simulations of cardiac electro-mechanics. Workshop on efficient solvers in biomedical applications, Graz, Austria.

28)   Nov 2012, Joakim Sundnes and Samuel Wall. Computational models of electro-mechanical interactions in the infarct injured heart. National PhD conference in medical Imaging, Trondheim, Norway.

29)   Aug 2012, B. F. Nielsen and Kent-A. Mardal. The Minimal Residual Method applied to ill-posed optimality systems; eigenvalues and convergence properties, Presented at the workshop "Numerical Methods for Optimal Control and Inverse Problems", Munich, Germany, 2012.

30)   Nov 2012, Joakim Sundnes, Samuel Wall, and Sjur Urdson Gjerald. Towards patient-specific models of strongly coupled cardiac electro-mechanics. Cardiac Physiome Workshop, San Diego, USA.

31)   July 2012, Joakim Sundnes and Samuel Wall. On the stability of operator splitting schemes for strongly coupled cardiac electro-mechanics. World Congress on Computational Mechanics, Sao Paulo, Brazil.

32)   Oct 30th-Nov 2nd, Maleckar MM. Towards Modeling Arrhythmogenic Cardiomyopathy – Can Simulation Shed Light on a Complex Disease Process? Cardiac Physiome Workshop, San Diego, 2012.

33)   March 9th, Maleckar MM. “An Introduction to the CCI and Simula Research Laboratory.” Presentation to Arbeiderspartiet. Simula Research Laboratory, Fornebu.

34)   Sept 22nd-25th, Jussi T. Koivumäki, Torsten Christ, Gunnar Seemann, Mary M. Maleckar, Divergent action potential morphology in human atrial cells vs. tissue: underlying ionic mechanisms, CinC Proceeding, 2012

35)   Feb 16th, Jussi T. Koivumäki, Excitation-contraction coupling in human atrial myocytes: remodeling in atrial fibrillation, Seminar at the Institute of Biomedical Engineering, Karlsruhe, Germany, 2012.

36)   Sept 9th, Jussi T. Koivumäki, Torsten Christ, Gunnar Seemann, Mary M. Maleckar, Divergent action potential morphology in human atrial cells vs. tissue: underlying ionic mechanisms, Computing in Cardiology conference, Krakow, Poland, 2012.

37)   Sept 16th, Jussi T. Koivumäki, Torsten Christ, Gunnar Seemann, Mary M. Maleckar, Divergent action potential morphology in human atrial cells vs. tissue: underlying ionic mechanisms, EWGCCE meeting, Nantes, France, 2012.

38)   Oct 31st, M.M. Maleckar, J. Koivumaeki, D. Belke, R.B. Clark, C. Kondo, W.R. Giles, Functional Consequences of Expression of Heart Sodium Channel Nav1.5 in Cardiac Fibroblasts and Myofibroblasts, Cardiac Physiome Workshop, San Diego, USA.

39)   Oct 27th, T. Edvardsen.  Symposium 3D strain. EAE Teaching course, Skopje Macedonia.

40)   Oct 27th, T. Edvardsen. Clinical application of myocardial deformation imaging – case reports. EAE Teaching course, Skopje Macedonia.

41)   Oct 27th, T. Edvardsen. How does deformation relate to contractility and myocardial function? EAE Teaching course, Skopje Macedonia.

42)   Oct 27th, T. Edvardsen. Fundamentals of 2D strain speckle tracking – Can speckle tracking echocardiography provide additional clinical information? EAE Teaching course, Skopje Macedonia.

43)   Oct, 2012, T. Edvardsen. Non-invasiv diagnostics in cardiomyoapthies. Oslo, Oct 2013. Annual meeting, Norwegian Society of Cardiology.


Dissemination measures for general public

Media outreach

1)       Only 1 out of 15 survives without a defibrillator. Dagbladet 2012, Sept 25th

2)       Promising teraphy against hypertension. The Norwegian Heart and Lung Patient Organization web. Sept 5th, 2012

3)       So dangerous is stress for you. Dagbladet 2012, Sept 14th, page1 and 12

4)       New treatment against high blood pressure. VG 2012, Aug 29th. Page 10.

5)       The hidden symptoms. VG 2012, June 14th, page 10-11

6)       Long waiting lists can lead to new infarcts. NRK 2012 June 8th

7)       The theories that can explain the mystery. VG p10-11. 2012 May 3rd

8)       Cardiac arrest in athletes. Bergens Tidende p 34-35. 2012 May 3rd. Adressenavisa p3.

9)       Screening can give false results. ABCnyheter, 2012, May 2nd

10)   Can be caused by genetic heart disease. NRK - radio, 2012, May 2nd

11)   Temporary autopsy report: Unclear diagnosis. VG 2012, May 2nd

12)   Genetic heart disease and sudden cardiac death. Morgennytt. Norwegian state broadcasting - television (NRK1) 2012, May 2nd

13)   Genetic heart disease. Nyhetene. Norwegian state broadcasting - radio (NRK-P1) 2012, May 2nd

14)   Cocaine abuse can cause myocardial infarct. Aftenposten p9, 2012 April 11th.

15)   Younger people suffers from myocardial infarct due to cocaine abuse. Dagbladet 2012 April 10th.

16)   Cocaine abuse and myocardial infarct. 2012 April 11th. Dagsavisen p10, Bergensavisen p14, Adresseavisen p6, Drammens Tidende p3, Haugesundsavis p15, Nordlys p7, Romerikets Blab p12, Sarpsborg Arbeiderblad p17, Tidens Krav p8, Tønsberg Blad p20.

17)   Success for RF ablation in atrial fibrillation. VG, 2012, Jan 19th, page 30.

 

Commercial results supported by the project

1)       6VT, a 4D transesophageal ultrasound probe with supportive visualization software (BT12)

 

Heart SFI