News

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Read about the latest publications from center members below.

You can see the full overview here.


Posted by: Piritta Oct 25, 2017

 

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Center Deputy Director of Scientific Computing, Samuel Wall from Simula Research Laboratory talked about image based patient specific mechanical modeling of the heart during the workshop on cardiac imaging of the right ventricle on Wednesday 11th of October.

These models can be applied to cardiac mechanics through accurate capture of image based metrics. The utility of computational models is in their ability to probe mechanical features that are difficult or impossible to directly measure, like mechanical stress and contractile forces, giving patient specific models a potential diagnostic value across a variety of disease states.

Posted by: Piritta Oct 17, 2017

 

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Jørg Saberniak will defend his doctoral thesis Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)- Impact of exercise on cardiac outcome, differential diagnoses and risk stratification of arrhythmic events on Friday 20th of October at Rikshospitalet at 13.15 o'clock, in seminar room 2(B2.U002)

His trial lecture Rhytm control in atrial fibrillation. Methods and indications will be at 10.15 in the same room.

The dissertation will be held in Norwegian.

Posted by: Piritta Oct 11, 2017

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There will be a workshop on cardiac imaging on October 11th in the meeting room in building 20 at Gaustad Hospital, starting at 12.oo o'clock.

The workshop covers different aspects of echocardiography and MR imaging of the RV, as well as the role of mathematical modeling and 3D printing in RV research.

See the agenda below.

Posted by: Piritta Sep 28, 2017

 

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Every year Center for Heart Failure Research organizes a Symposium on Heart Failure that brings together basic scientist and clinical researchers from three continents, focusing on translational cardiology that promotes and integrates high quality research from bench to bedside.

Center postdoc Mathis Korseberg Stokke, MD, PhD is head of the organization commitee. He is also part of the administration of NORHEART – The Norwegian PhD School of Heart Research that offers targeted educational activities for Norwegian PhD students in cardiovascular research.

One of the cornerstones of the Symposium is the poster sessions on Thursdays, giving young and established scientists a chance to show their best to colleagues from the forefront of international science and leadership in cardiology and cardiovascular research.

Each year, the PhD fellows from the Center for Cardiological Innovation present the latest of results from their research, this year having posters in sessions for “Cardiac function during heart failure and exercise training”, “Cellular signaling: myocardial function and arrhythmias” and “Diagnostic and therapeutical strategies for cardiac disease”.  The best poster in each session is awarded with a prize worth 5000 nok, given by NORHEART.

So far following center members have taken home the prize; Ida Skrinde Leren, MD, PhD, Nina Hasselberg, MD, PhD, John Aalen, MD, PhD fellow and Øyvind Lie, MD, PhD fellow. This is the second time Lie has won the prize, and earlier this year center member Ida Skrinde Leren was awarded with H.M. the King's gold medal for the best medical PhD during 2016. The medal is awarded to an outstanding, young researcher for a scientific work assessed at the University of Oslo. The work must be recognized as an effective contribution to the field of research's literature.

Posted by: Piritta Sep 27, 2017

 

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Ida Skrinde Leren har vært stipendiat hos Center for Cardiological Innovation og Nasjonalforeningen for folkehelsen fra mars 2013 til juni 2016. Doktorgradsarbeidet har vært utført ved kardiologisk avdeling, OUS Rikshospitalet, og kardiolog og førsteamanuensis Kristina Haugaa har vært hovedveileder. Professor og kardiolog Thor Edvardsen har vært biveileder.
Leren disputerte 15. juni 2016, med avhandlingen “Ventricular arrhythmias in cardiac ion channel diseases; occurrence, treatment and risk stratification”, og 1. september 2017 ble hun tildelt H.M Kongens gullmedalje for arbeidet.

Posted by: Piritta Sep 5, 2017
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The year’s biggest happening within cardiology gathers cardiovascular professionals from over 140 countries, coming together to explore the latest research and development within the field. During the congress more than 4000 abstracts are showcased, selected from over 10 000 submitted ones in the relentless pursuit of excellence that ESC has taken as one of its core values.

As Jeroen J. Bax, FESC, President of the European Society of Cardiology, stated under the Inaugural Session on Saturday 26th of August, never before has the congress been so global and so accessible. Each year over 30 000 participants travel to a selected location in Europe to share their knowledge. In addition, the congress registered over 286 500 online visits last year.

Among those presenting the latest research results from the center were PhD fellows Øyvind Lie, MD and John Aalen, MD, which were both selected to present their research under the Rapid Fire Oral Sessions. Consultant cardiologist Mette-Elise Estensen, MD, PhD, discussed timing and mode of re-intervention in Tetralogy of Fallot under the session “Long-term management and risk assessment after Tetralogy of Fallot repair”.

Oslo University Hospital and CCI partakes in a Nordic multicenter study looking into the treatment and predictors for disease progress in arrhythmogenic cardiomyopathy (AC). Studies presented focused on predictors of ventricular arrhythmias in AC and primary prevention of sudden death with ICD therapy.

Posted by: Piritta Sep 4, 2017

 

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Friday 1st of September OUH welcomes renowed international cardiologists for a symposium on heart failure with preserved ejection fraction (HFpEF), organized under the auspices of Yonsei University College of Medicin and University of Oslo.

The symposium will adress important new insights into HFpEF, including biomarkers, the clinical application of LV vortex flow analysis and diastolic dysfunction in organ rejection.

Øyvind Senstad Andersen, MD, PhD fellow, will be discussing the use of echogardiography in the assessment of LV filling pressure.

Copyright Apeland, Katrine Lunke

 

The symposium begins at 10.00 o'clock in the meeting room for the Division of Cardiovascular and Pulmonary Diseases at Rikshospitalet.

Posted by: Piritta Aug 25, 2017

 

Onsdag 16. august inviterte CCI til markering av en ny hjerteultralydskanner som skal lanseres under den presisjefylte ESC (European Society of Cardiology) kongressen i slutten av august.

Forskere ved Oslo universitetssykehus (OUS), Rikshospitalet og ingeniører ved GE Vingmed Ultrasound (GEVU) har i en årrekke samarbeidet med å utvikle en ultralydskanner som gjør det enklere for verdens kardiologer å diagnostisere forskjellige hjertesykdommer for å kunne tilby hver enkelt pasient målrettet behandling.

- Det er viktig å få overført kunnskapen som  leger innehar til kliniske verktøy som kommer pasienter til gode, vi kan ikke bare ha fokus på publikasjoner, sa senterleder Thor Edvardsen under markeringen av skanneren. Samarbeidet mellom klinikere og industri er vesentlig og har nå ført til enda et gjennombrudd, nemlig utviklingen av en ny metode kalt Myocardial Work. Et mulig bruksområde for den nye metoden er å avgjøre om en pasient er tjent med biventrikulær pacemaker eller ikke. Frem til nå har man ikke hatt gode nok metoder til dette formålet. Omtrent 40% av pasientene som har fått slik pacemaker, opplever dessverre ingen effekt av behandlingen.

Fra venstre; Professor Otto Smiseth (OUS), professor Eigil Samset (GEVU), Gunnar Hansen (GEVU), lege og stipendiat Øyvind Lie (OUS), professor Thor Edvardsen (OUS).

Posted by: Piritta Aug 18, 2017

 

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Christine Rootwelt, MD
Eystein Skjølsvik, MD
PhD fellow
Pål Brekke, MD, PhD


CCI welcomes new center members.

Posted by: Piritta Jul 12, 2017

 


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Capturing physiological variability and validating models is a main challenge in cardiac mathematical modeling, a field that is becoming increasingly important in modern cardiological research.  Siri Kallhovd has studied the sensitivity of computational results to model parameters, her thesis including an exploratory study of the influence of several factors related to fatty tissue infiltration, with the ultimate goal of arrhythmia risk evaluation.

She successfully defended her PhD thesis "Computational tools for clinically driven models of cardiac electro-mechanics"  on Thursday 15th of June. Read more about her defense and PhD thesis on Simula’s webpage.

Photo courtesy of Simula/Karoline Hagane
Posted by: Piritta Jul 6, 2017
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The 28th Annual American Society of Echocardiography Scientific Sessions will convene in Baltimore, Maryland during June 2nd to 6th.

From the basics of clinical imaging to the most sophisticated advances in microbubble gene delivery to the determination of its best use in value-driven healthcare, ASE aims to present how echocardiography is best utilized today, and what’s in store for tomorrow.

Read the program here.
Posted by: Piritta May 30, 2017

 

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Center for Cardiological Innovation deltok i årets Holmenkollstafett under kategorien «A1 Andre lag mix flertall menn» og kom på plass 229 i sin kategori med tiden 1:12:00  :) !

Laget var blant topp 15% og fikk tildelt medalje for sin innsats. Totalt var det 1506 lag som konkurrerte i kategorien.

Alt i alt var det 3037 lag som deltok i Norges største friidrettsarrangement som strekker seg fra Louisesgate, gjennom Frognerparken til Bislett.

Se tidene til løperne her

Bilde tatt av Pål Brekke
Posted by: Piritta May 16, 2017
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Cardiac function from a calcium perspective

NORHEART in collaboration with the Institute for Experimental Medical Research invites everyone to the workshop Cardiac function from a calcium perspective.

Invited lectures:

– “Calcium in the heart: Where do we go from here?”
David Eisner, Unit of Cardiac Physiology, University of Manchester, UK

– “Triggered calcium waves and atrial fibrillation: Approaching a mechanism?”
J. Andrew Wasserstrom, Department of Medicine (Cardiology) and the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, USA.

Participation is free and open to everyone

NORHEART will cover expenses for travel and accommodation for all NORHEART student members.

Time: Wednesday June 7th, 12:00 – 15:00 (lunch 11.30-12.00)

Location: Meeting room at Institute for Experimental Medical Research (building 7, 4th floor, Oslo University Hospital Ullevål)

Please register within June 5th via registration link or e-mail: a.t.roe@medisin.uio.no

Posted by: Piritta May 12, 2017

 

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Senter administrator Piritta Nyberg fortalte om formidling av senterets aktiviteter under årets SFI-forum, som også hadde rekorddeltagelse.

CCI har lyktes i å høste god medieomtale som er med på å profilere både senteret og den viktige forskningen senterets medlemmer gjør.

Forskningsrådet understrekte at det nå vil bli viktigere enn noen gang at SFI-sentrene selv tar ansvar for formidling av resultater i fremtiden.

Bilde Nils Ragnar Løvhaug / Nucleus
Posted by: Piritta May 5, 2017

 

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Welcome  to CCI Workshop with Professors  Mark Friedberg and Mani Vannan on May 8th at Rikshospitalet, hosted in collaboration with NORHEART.

Center members will present data from center studies on mitral valve prolapse, aortic stenosis, Fallot tetralogy, ARVC and new projects in oncology will be presented.

Chairing the workshop will be Professor Thor Edvardsen and Associate professor Kristina Haugaa.

The workshop also comprises two exciting lectures by invited speakers:

- "What causes RV dysfunction in repaired Tetralogy of Fallot?"
Prof Mark Friedberg, The Hospital for Sick Children, Toronto, Canada

- "How to and why to do 3-D Echo in your echo lab?"
Prof Mani Vannan, Piedmont Heart Institute, Fuqua Heart Center, Piedmont Atlanta Hospital, USA

Posted by: Piritta May 2, 2017

 

Flere sentermedlemmer vil holde presentasjoner under årets NCS Høstmøte i Trondheim 8-10 juni.

Blant foredragsholdere er overlege Mette Estensen, som kommer til å snakke om akutt hjertesykdom hos gravide, og senterleder for kardiologisk forskning Kristina Haugaa, som vil fortelle om risikovurdering og behandling av ventrikulære ekstrasystoler.

Senterleder Thor Edvardsen retter blikket mot fremtiden med foredraget "Kardiale bildeundersøkelser inn i fremtiden".

Se program for fullstendig oversikt.

Posted by: Piritta May 2, 2017

 

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Velkommen til kurs om kvinnehjertet 7. juni!

Hjerte-karsyke pasienter kan nå behandles selv etter de har fylt 80 år, som resultat av ny kunnskap og teknologi. Dette vil særlig komme kvinner til gode fordi de lever lengst.

På kurset Nytt om kvinnehjertet - Fra mors liv til 80+ vil blant annet overlege Bjørn Bendz fortelle om ny behandling av hjerteklaffsykdom, som gjør at pasienten kan få satt inn en ny hjerteklaff via lysken (TAVI).

Livsstil og svangerskap påvirker hjertet

Kurset er beregnet for helsepersonell, forskere og helsemyndigheter som vil oppdatere seg på den nyeste kunnskapen om kvinnehjertet i et livsløpsperspektiv.

Deltagerne får blant annet høre om hvordan livsstil og svangerskapsforgiftning påvirker hjertet, fra henholdsvis professor Dag Thelle fra Nasjonalforeningen for Folkehelse og professor Anne Cathrine Staff.

Kurset arrangeres av Nasjonalkompetansetjeneste for kvinnehelse, Nasjonal behandlingstjeneste for hjertesyke gravide, Folkehelseinstituttet og Nasjonalforeningen for Folkehelse.


Posted by: Piritta May 2, 2017

 


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Results from several recent studies have been published in international scientific journals this year, including an expert consensus document on multi-modality imaging approaches in arrhythmogenic cardiomyopathies.

Below is a short overview of the following articles;
- Comprehensive multi-modality imaging approach in arrhythmogenic cardiomyopathy-an expert consensus document of the European Association of Cardiovascular Imaging
- Echocardiographic comparison between left ventricular non-compaction and hypertrophic cardiomyopathy
- Soluble ST2 is associated with disease severity in arrhythmogenic right ventricular cardiomyopathy
- A retrospective analysis of cardiovascular outcomes in patients treated with ASV

Posted by: Piritta Apr 24, 2017

 

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Unikard skriver om studier gjennomført ved CCI. Studiene til senter Postdoc Kristin McLeod, Ida Skrinde Leren, MD, PhD, senter PhD-stipendiat Øyvind Senstad Andersen, MD og seniorforsker Mary Maleckar, PhD er omtalt. Du kan lese kort om følgende studier under.

- Ventricular structure in ARVC: going beyond volumes as a measure of risk.
- Combination of ECG and Echocardiography for Identification of Arrhythmic Events in Early ARVC.
- Estimating Left Ventricular Filling Pressure by Echocardiography.
- Studying dyadic structure–function relationships: a review of current modeling approaches and new insights into Ca (mis)handling

Posted by: Piritta Apr 24, 2017

 


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Several center members have published results from their studies in international scientific journals this year.

Below you can read a short overview of the following articles;
- Left ventricular dysfunction is related to the presence and extent of a septal flash in patients with right ventricular pacing
- High-Sensitivity Troponin T vs I in Acute Coronary Syndrome: Prediction of Significant Coronary Lesions and Long-term Prognosis
- Temperature monitoring by channel data delays: Feasibility based on estimated delays magnitude for cardiac ablation
- Focused cardiac ultrasound by unselected residents-the challenges
- Real-time catheter localization and visualization using three-dimensional echocardiography

Posted by: Piritta Apr 24, 2017

 

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The year 2016 has been very successful for CCI. Among the highlights was a visit from Minister of Education and Research Torbjørn Røe Isaksen and Director of the Research Council of Norway Arvid Hallén in May 2016.

Center Director Professor Thor Edvardsen became the new President Elect of the European Association of Cardiovascular Imaging (EACVI), and Prof. Otto Smiseth was rewarded with the EACVI Honorary Membership in recognition of his outstanding contribution in the field of Cardiovascular Imaging.

Four center membrs successfully defended their PhD-thesis.

Read more about it in the annual report.

Posted by: Piritta Mar 29, 2017

 

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Gabriel Balaban, M.Sc, PhD forsvarte sin doktoravhandling Adjoint Data Assimilation Methods for Cardiac Mechanics i januar og har fortalt Titan om sin forskning ved CCI.

Ved å bruke data fra medisinske ekkoloddbilder har Balaban sammen med sine kollegaer utviklet metoder som gjør det mulig å lage personlige modeller av hjertebevegelser. Leger bruker ekkobilder til å stille diagnoser og planlegge behandling av forskjellige hjertesykdommer. Bevegelsesmønsteret til hjertet sier noe om tilstanden og utviklingen av sykdommen.

– Men utviklingen av disse sykdommene påvirkes også av elastiske krefter og hjertemusklenes evne til å trekke seg sammen. Disse tingene kan man ikke se på bildene alene, men de kan i stedet beregnes ved hjelp av en matematisk modell utviklet for den enkelte pasient, sier forsker Gabriel Balaban til Titan.

Metodene Balaban har vært med på å utvikle gir modellen bedre oppløsning og nøyaktighet, og kan hjelpe leger med blant annet å plassere de elektriske ledningene til en pacemaker så nøyaktig som mulig, og dermed sikre bedre pasientbehandling i fremtiden.

Les mer på hjemmesiden til Titan.


Posted by: Piritta Mar 26, 2017

 


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Flere sentermedlemmer bidro med referater fra de største kongressene og møtene som pågikk høsten og tidlig vinter 2016 i årets første utgave av Hjerteforum.
Du kan lese alle sammen med tillatelse fra Norsk cardiologisk selskap (NCS), linkene finner du i tekstene under. Blant bidragsytere er PhD-stipendiater, overleger og senterleder Thor Edvardsen.

Senter postdoc Mathis K. Stokke skriver om mikrovolt T-bølgealternans mens senterleder for kardiologisk forskning Kristina Haugaa tar for seg arytmirisiko og vurdering ved forskjellige kardiomyopatier. Lars Gunnar Klæboe, som også presenterte sin poster under AHA Scientific Sessions 2016 har skrevet et referat om nytten av strain-analyser ved ulike kardiale tilstander belyst under sesjonen for "Myocardial strain imaging" under samme kongresse.

Posted by: Piritta Mar 21, 2017

 

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Under fredagens stabsmøte for ansatte ved Rikshospitalet snakket senterledelsen og PhD-stipendiat Øyvind H. Lie om hjertets genetikk, trening og plutselig død.

Forskning ved CCI har de siste årene bidratt med mye ny kunnskap om genetiske hjertesykdommer og diagnostisering av disse.

Førsteamanuensis Kristina H. Haugaa og professor Thor Edvardsen har, sammen med flere andre europeiske eksperter, nylig publisert et ekspert konsensus dokument på vegne av European Association of Cardiovascular Imaging.


Retningslinjene omhandler bruk av bildebehandling i diagnostisering arytmogen kardiomyopati. «Comprehensive multi-modality imaging approach in arrhythmogenic cardiomyopathy-an expert consensus document of the European Association of Cardiovascular Imaging» er publisert i Eur Heart J Cardiovasc Imaging. (2017 Jan 9. pii: jew229. doi: 10.1093/ehjci/jew229.)
Artikkelen (dokumentet) gir kliniske anbefalninger til hvordan å bruke multi-modal bildebehandling i de forskjellige aspektene ved arytmogen kardiomyopati, inkludert diagnose, screening av familiemedlemmer, oppfølgning, risikovurdering og differensialdiagnose.

Posted by: Piritta Feb 6, 2017
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Overlege Kristina Haugaa og sykepleier Katrine Onshuus Eriksen ved kardiologisk avdeling er tildelt forskningsstøtte på til sammen 780.000 kroner fra Foreningen for hjertesyke barn.

Overlege og førsteamanuensis Kristina Haugaa leder fagenheten for genetisk hjertesykdom ved kardiologisk avdeling, et fagfelt som er i stor vekst.
Midlene hun har fått tildelt skal brukes til å utarbeide felles landsdekkende retningslinjer for oppfølging og behandling av pasienter og familier med genetisk hjertesykdom.

Sykepleier Katrine Onshuus Eriksen jobber til daglig med voksne med medfødt hjertefeil og skal bruke midlene til å gjøre en kartlegging av psykososial status hos voksne med medfødt hjertefeil.
Målet med kartleggingen er  å utvide kunnskapsgrunnlaget slik at man kan bedre den helhetlige ivaretagelsen av pasientgruppen ved å tilpasse oppfølgningstilbudet.

Kristina Haugaa og
Katrine Onshuus Eriksen
Tekst av Hedda Holt (Oslo Universitetssykehus).
Posted by: Piritta Jan 24, 2017

 

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M.Sc. Gabriel Balaban at the Department of Informatics will be defending his dissertation for the degree of Ph.D: Adjoint Data Assimilation Methods for Cardiac Mechanics.

Time for the trial lecture is set at 10.00 o'clock on Tuesday 10th of January at "Storstua" Simula-senteret, Martin Linges vei 17, Fornebu. The dissertation will take place in the same room at 13.00 o'clock.

Posted by: Piritta Jan 2, 2017

 

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One of the largest gatherings in the field of cardiovascular imaging, EuroEcho-Imaging Conference, was held in Leipzig, Germany this year. More than 3 200 healthcare professionals from over 90 countries met for a 4-day long scientific exchange. Several Center members participated, presenting the data from recent studies.

During the conference it was announced that Center Director Thor Edvardsen has become the new President Elect of the European Association of Cardiovascular Imaging (EACVI). This is an enormous honor and is the first time that someone from the Nordic countries has been elected to this prestigious position. Professor Edvardsen won the Inge Edler prize earlier on this year. The award is given for outstanding contribution in the field of echocardiography.

Professor Otto Smiseth was rewarded with EACVI Honorary Membership in recognition of his outstanding contribution in the field of Cardiovascular Imaging during the conference.

Posted by: Piritta Dec 30, 2016

 

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CCI congratulates to center director Thor Edvardsen who was announced as the new President Elect of the European Association of Cardiovascular Imaging (EACVI) during the EuroEcho conference!

This is the first time that someone from the Nordic countries has been elected to this prestigious position. EACVI is the world leading organization for cardiovascular imaging, promoting excellence in clinical diagnosis, research, technical development and education in cardiovascular imaging in Europe.

Professor Edvardsen, who has previously been Chair of the EACVI Scientific Documents Committee, is also Head of Department of Cardiology at Oslo University Hospital.

Posted by: Piritta Dec 9, 2016

 

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AHA Scientific Sessions took place in mid-November in New Orleans, Louisiana, USA. Several center members participated and presented the most recent results of their research. Read the program here.

Some of the highlights include results showing that strain by FTMRI in combination with noninvasive LV pressure demonstrates marked asymmetry in distribution of segmental work in patients with LBBB, and that mechanical dispersion by speckle tracking echocardiography is associated with adverse outcome in conservatively treated patients with aortic stenosis independently of left ventricular ejection fraction and age.

Posted by: Piritta Dec 9, 2016
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