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Study on risk prediction of malignant arrhythmias in cardiac laminopathies published in Europace journal

Christine Rootwelt-Norberg, copyright Åsne Rambøl Hillestad, UiO

PhD-fellow Christine Rootwelt-Norberg, professor Kristina Haugaa and co-authors published a paper on risk prediction of malignant arrhythmias in patients with cardiac laminopathies in EP Europace journal in November (1). 94 LMNA genotype positive patient were followed for 5 years, and a total of 536 echocardiographic and 266 ECG examinations were analysed. Disease progression rates by ECG and echocardiography were strong predictors of future arrhythmic event, and importantly, the disease progression rates had added value to the absolute measurements. Transition to a more arrhythmogenic phenotype was seen at left ventricular ejection fraction 44% and PR interval duration 280 ms.   

The study was also presented at EACVI congress in December 2021 were Rootwelt-Norberg was awarded the Young Investigator Award in clinical science, and at the EHRA congress in April 2022.

1) Disease progression rate is a strong predictor of ventricular arrhythmias in patients with cardiac laminopathies: a primary prevention cohort study
Christine Rootwelt-Norberg, Eystein T Skjølsvik, Monica Chivulescu, Martin P Bogsrud, Margareth P Ribe, Eivind W Aabel, Jan Otto Beitnes, Pål H Brekke, Trine F Håland, Nina E Hasselberg, Øyvind H Lie, Kristina H Haugaa
EP Europace, euac192, https://doi.org/10.1093/europace/euac192
PMID: 36352512