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Postdoctoral fellow at ProCardio Marit Kristine Smedsrud has published a study on children with ARVC in the European Heart Journal

Marit Kristine Smedsrud presents her study at ESC 2022. Copyright (c) OUS

Postdoktor ved ProCardio og overlege ved Barnekardiologisk avdeling Marit Kristine Smedsrud og professor Kristina Haugaa, sammen med medforfattere, publiserte artikkelen «Highly malignant disease in childhood-onset arrhythmogenic right ventricular cardiomyopath» i det anerkjente tidsskriftet European Heart Journal (1) i slutten av august.

Part of the research group from ProCardio at ESC 2022. Copyright (c) OUS

Postdoctoral fellow at ProCardio and pediatric cardiologist at the Department of Pediatric Cardiology, Marit Kristine Smedsrud, and professor Kristina Haugaa, together with co-authors, published the study "Highly malignant disease in childhood-onset arrhythmogenic right ventricular cardiomyopathy" in the highly ranked European Heart Journal (1) in early August. This study aimed to explore the incidence of severe cardiac events in pediatric ARVC patients and the yield of family screening for ARVC in childhood.  In a pediatric ARVC cohort, there was a high incidence of severe cardiac events and half of them occurred in children ≤12 years of age. The ARVC penetrance in genotype positive pediatric relatives was 18%. These findings of a high-malignant phenotype in childhood-onset ARVC indicate a need for ARVC family screening at younger age than currently recommended. The study was recently commented in an Editorial (2) by pediatric cardiologist Juan Pablo Kaski at Great Ormond Street Hospital, London, UK.

The study was also presented at the ESC Congress in Barcelona in August.

1)      Highly malignant disease in childhood-onset arrhythmogenic right ventricular cardiomyopathy. Smedsrud MK, Chivulescu M, Forså MI, Castrini I, Aabel EW, Rootwelt-Norberg C, Bogsrud MP, Edvardsen T, Hasselberg NE, Früh A, Haugaa KH.Eur Heart J. 2022 Aug 29:ehac485. doi: 10.1093/eurheartj/ehac485. PMID: 36036653

2)      Arrhythmogenic cardiomyopathies in children: seek and you shall find. Kaski JP.Eur Heart J. 2022 Oct 20:ehac585. doi: 10.1093/eurheartj/ehac585. Online ahead of print.PMID: 36263790